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Briefly, cholesterol (2% w/w) powder was thoroughly mixed with crushed pellet diet and reconstituted with water and allowed to dry properly to prevent microbial contamination.Experimental design Thirty-six male rats were divided into six groups (six animals each) after 2 weeks of acclimatization.Animals Male Wistar albino rats (180–210) g were used for the present study.They were maintained at standard laboratory conditions (temperature 22 ± 1°C: photoperiod: 12 h light and dark cycle each throughout the experimental period; humidity: 45–50%) and fed with standard commercial rats pellet diet (Alanko feeds, Mokola, Ibadan) water ad libitum .In spite, of the reported local use of the Talinum triangulare in the management of cardiovascular diseases, there is still a paucity of information on its antilipidemic, antioxidant potential, and effect on blood parameters.Therefore, the present study was designed to investigate the effect of leaf extract Talinum triangulare (Jacq). on lipid profile, oxidative stress and hematological indices in animal model.
Leave preparation was done according to the method described by C with continuous turning for 3 days to avert fungal growth.
Effect of methanolic leaf extract of Talinum triangulare (Jacq). on biochemical parameters in diet induced dyslipidemia wistar rats.
Phcog Mag 2016;3-9How to cite this URL: Olorunnisola OS, Adetutu A, Afolayan AJ, Owoade AO.
Phcog Mag [serial online] 2016 [cited 2018 Feb 5];3-9. 2016/12/48/333/192194 One possible mechanism by which hyperlipidemia contributed to the development of cardiovascular diseases involved the generation of free radicals [malondialdehyde (MDA) and conjugated dienes] and decrease antioxidant enzyme (superoxide dismutase, catalase and glutathione peroxidase) activities and nonenzymatic antioxidants (vitamin C and E) status.
It is an established fact that most of the orthodox drugs (statins and fibrates) commonly employed in the treatment of cardiovascular diseases are tailored to correct the deranged blood lipid profile, whereas some of them act by inhibiting the biosynthesis of cholesterol or enhancing the clearance of triglyceride.